John F. Enders and measles virus vaccine--a reminiscence.

Chapter 1 John F . Enders and Measles Virus Vaccine — a Reminiscence

Following their initial isolation in cell culture of the virus in 1954, a succession of investigators under the mentorship of John F. Enders conducted the research, development, and initial clinical studies responsible for the licensure in 1963 of a successful live attenuated measles virus vaccine. Propagation of the virus successively in human kidney cells, human amnion cells, embryonated hens...

Cultivation of measles virus in sheep kidney cells.

Since the first isolation of measles virus in human and monkey renal cells by Enders and Peebles (1), the virus has been grown in primary cultures of human amnion (5, 6), chick en\.bryo (3), dog kidney (2), bovine kidney (4,8), and guinea pig kidney (9). Sorne of these tissues have now even been employed for the production of measles vaccine. This report presents our data indicating the high su...

Evaluation of Measles Vaccine Virus as a Vector to Deliver Respiratory Syncytial Virus Fusion Protein or Epstein-Barr Virus Glycoprotein gp350

Live attenuated recombinant measles vaccine virus (MV) Edmonston-Zagreb (EZ) strain was evaluated as a viral vector to express the ectodomains of fusion protein of respiratory syncytial virus (RSV F) or glycoprotein 350 of Epstein-Barr virus (EBV gp350) as candidate vaccines for prophylaxis of RSV and EBV. The glycoprotein gene was inserted at the 1(st) or the 3(rd) position of the measles viru...

Sequence Variation in Measles Virus F Gene of AIK-C Vaccines Strain after Passage in Vero Cells

Vaccination Against Measles: Francis Home Redivivus

This paper is an attempt to review in the light of earlier research certain recent work on measles virus with emphasis on the development of a living attenuated vaccine against the disease. It was presented as a Cameron Prize Lecture before the Faculty of Medicine, Edinburgh University, 16 May 1961. Since it has not been submitted for publication the author decided it might be appropriate to of...